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One-Step Synthesis of Pyrido[1,2-α]benzimidazole Derivatives by a Novel Multicomponent Reaction of Chloroacetonitrile, Malononitrile, Aromatic Aldehyde, and Pyridine.
- Source :
-
Journal of Organic Chemistry . 1/16/2009, Vol. 74 Issue 2, p710-718. 9p. 6 Diagrams, 3 Charts. - Publication Year :
- 2009
-
Abstract
- Polysubstituted pyrido[1,2-α]benzimidazole derivatives are efficiently produced in moderate yields in a novel one-pot, four-component reaction from pyridine or 3-picoline, chloroacetonitrile, malononitrile, and aromatic aldehyde in refluxing acetonitrile. The mechanism of this novel reaction was believed involving the formation of polysubstituted benzenes with subsequent substitution and annulation reaction of pyridine. All pyrido[1,2-α]benzimidazoles, polysubstituted benzenes, polysubstituted indoles, and some key reaction intermediates are characterized by 1H and 13C NMR, MS, IR spectra, and elemental analysis as well as X-ray crystallography. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 74
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 36122382
- Full Text :
- https://doi.org/10.1021/jo802166t