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HOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells
- Source :
-
Biochemical & Biophysical Research Communications . Jan2009, Vol. 379 Issue 1, p16-21. 6p. - Publication Year :
- 2009
-
Abstract
- Abstract: Implantation is the first maternal–embryo crosstalk that only occurs during a finite period called the ‘implantation window’. HOXA10, a homeobox transcription factor, plays an important regulatory role during this period. However, the target genes of HOXA10 involved in implantation and decidualization have not been identified. Using a chromatin immunoprecipitation screen, we identified the p300/CBP-associated factor (p/CAF) as a direct HOXA10 target gene in vivo. Adenovirus-mediated overexpression and siRNA-specific knockdown of HOXA10 altered p/CAF promoter activity via interaction with the three consecutive TTAT element units in human endometrial cells. These results indicate that p/CAF is a novel HOXA10 target gene, and HOXA10 promotes human endometrial development, at least in part, through the regulation of p/CAF gene. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 379
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 36139398
- Full Text :
- https://doi.org/10.1016/j.bbrc.2008.11.144