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Alcohol consumption and transition of mild cognitive impairment to dementia.
- Source :
-
Psychiatry & Clinical Neurosciences . Feb2009, Vol. 63 Issue 1, p43-49. 7p. 1 Chart, 2 Graphs. - Publication Year :
- 2009
-
Abstract
- Aim: Mild cognitive impairment (MCI) is a prodrome for dementia. Alcohol drinking patterns may affect cognitive functions and the effects may accumulate to a significant level at an advanced age. This study investigated the relationship between alcohol consumption and risks for dementia in a cohort of elderly patients with MCI. Methods: Patients with suspected cognitive impairment were screened. One hundred and seventy-six patients who met the MCI criteria were enrolled. Lifetime and daily alcohol consumptions were assessed at baseline using a self-report questionnaire answered by patients and their caregivers. Patients were classified according to alcohol consumptions as abstainers, light–moderate and heavy drinkers. Global cognitive functions were assessed periodically with Mini-Mental State Examination (MMSE). Enrolled patients were followed for 2 years. Results: Of the 176 patients diagnosed as having MCI, 15 (8.5%) died, 13 (7.4%) were lost to follow up, and 66 (37.5%) developed dementia during follow up. Light–moderate alcohol drinkers had better MMSE performance than abstainers ( P < 0.05) and heavy drinkers ( P < 0.01) 2 years after MCI diagnosis. Patients who consumed a total of ≤300 kg alcohol prior to MCI diagnosis had less cognitive decline than patients who consumed no ( P < 0.05) or >300 kg alcohol ( P < 0.01). Heavy drinkers had a higher risk for dementia than abstainers ( P < 0.05) and light–moderate drinkers ( P < 0.05) 2 years after MCI diagnosis. Conclusions: A J-shaped relationship may exist between alcohol consumption and cognitive decline in MCI patients. Light–moderate alcohol drinking may be associated with decreased risks for dementia in elderly patients with MCI. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALCOHOLISM
*ALCOHOL drinking
*COGNITION disorders
*DEMENTIA
*PEOPLE with alcoholism
Subjects
Details
- Language :
- English
- ISSN :
- 13231316
- Volume :
- 63
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Psychiatry & Clinical Neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 36141943
- Full Text :
- https://doi.org/10.1111/j.1440-1819.2008.01904.x