A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer.

Authors :: Ogino, Shuji
Nosho, Katsuhiko
Kirkner, Gregory J.
Kawasaki, Takako
Chan, Andrew T.
Schernhammer, Eva S.
Giovannucci, Edward L.
Fuchs, Charles S.
Source :: JNCI: Journal of the National Cancer Institute. 12/3/2008, Vol. 100 Issue 23, p1734-1738. 5p. 1 Chart, 1 Graph.
Publication Year :: 2008
Abstract: The article offers information on a cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. It states that genome-wide DNA hypomethylation occupies an essential role in genomic instability and colorectal carcinogenesis. The study identified that tumoral LINE-1 hypomethylation is independently related with shorter survival among patients of colon cancer. The authors in this study used 643 colon cancers in two independent prospective cohorts.