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Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant: report of clinical response to treatment with tigecycline.
- Source :
-
Transplant Infectious Disease . Feb2009, Vol. 11 Issue 1, p57-63. 7p. 4 Black and White Photographs, 3 Charts. - Publication Year :
- 2009
-
Abstract
- We present a case of progressive Mycobacterium chelonae ssp. chelonae necrotizing pneumonia after hematopoietic stem cell transplantation (HSCT) in the presence of chronic graft-versus-host disease. The patient failed to respond to standard combination therapy with multiple agents and developed resistance to most drugs over the course of treatment. Tigecycline, a new glycylcycline antimicrobial agent with in vitro activity against M. chelonae, was then used with a clinical response to treatment. To our knowledge, this is the first reported case demonstrating tigecycline to have a degree of clinical effectiveness to treat refractory pulmonary infection with M. chelonae in an HSCT recipient. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13982273
- Volume :
- 11
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Transplant Infectious Disease
- Publication Type :
- Academic Journal
- Accession number :
- 36162124
- Full Text :
- https://doi.org/10.1111/j.1399-3062.2008.00351.x