Genetic thrombophilia variants and risk for preeclampsia among American Indians.

<bold>Objective: </bold>To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.<bold>Methods: </bold>A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.<bold>Results: </bold>The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.<bold>Conclusion: </bold>The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia. [ABSTRACT FROM AUTHOR]