Putting pressure on elusive polymorphs and solvatesElectronic Supplementary Information (ESI) available: X-ray powder diffraction patterns of malonamide up to 5.0 GPa. Experimental and simulated X-ray powder diffraction patterns of malonamide (forms I and II) and maleic acid (form II). See DOI: 10.1039/b814471k/

The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce ‘bulk’ quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration. [ABSTRACT FROM AUTHOR]