Conjugated Linoleic Acid Combined With Creatine Monohydrate and Whey Protein Supplementation During Strength Training.

Purpose: The authors examined the combined effects of conjugated linoleic acid (CLA), creatine (C), and whey protein (P) supplementation during strength training. Methods: Sixty-nine participants (52 men, 17 women; M ± SD age 22.5 ± 2.5 yr) were randomly assigned (double-blind) to 1 of 3 groups: CCP (6 g/d CLA + 9 g/d C + 36 g/d P; n = 22), CP (C + P + placebo oil; n = 25), or P (P + placebo oil; n = 22) during 5 wk of strength training (4-5 sets, 6-12 repetitions, 6 d/wk). Measurements were taken for body composition (air-displacement plethysmography), muscle thickness (ultrasound) of the flexors and extensors of the elbow and knee, 1-repetitionmaximum (1-RM) strength (leg press and bench press), urinary markers of bone resorption (N-telopeptides, NTx), myofibrillar protein catabolism (3-methylhistidine; 3-MH), oxidative stress (8-isoprostanes), and kidney function (microalbumin) before and after training. Results: Contrast analyses indicated that the CCP group had a greater increase in bench-press (16.2% ± 11.3% vs. 9.7% ± 17.0%; p < .05) and legpress (13.1% ± 9.9% vs. 7.7% ± 14.2%; p < .05) strength and lean-tissue mass (2.4% ± 2.8% vs. 1.3% ± 4.1%; p < .05) than the other groups combined. All groups increased muscle thickness over time (p < .05). The relative change in 3-MH (CCP -4.7% ± 70.2%, CP -0.4% ± 81.4%, P 20.3% ± 75.2%) was less in the groups receiving creatine (p < .05), with the difference for NTx also close to significance (p = .055; CCP -3.4% ± 66.6%, CP -3.9% ± 64.9%, P 26.0% ± 63.8%). There were no changes in oxidative stress or kidney function. Conclusion: Combining C, CLA, and P was beneficial for increasing strength and lean-tissue mass during heavy resistance training. [ABSTRACT FROM AUTHOR]