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Role of TNF-α Gene Variation in Idiopathic Childhood Ischemic Stroke: A Case-Control Study.
- Source :
-
Journal of Child Neurology . Jan2009, Vol. 24 Issue 1, p25-29. 5p. 2 Charts. - Publication Year :
- 2009
-
Abstract
- Etiology of the idiopathic childhood stroke remains unknown. In previous studies, the immunologic process may be involved in the idiopathic stroke. Tumor necrosis factor- alpha (TNF-α), an important immune mediator, may contribute to the initiation and progression in the stroke. The main purpose of this study was to investigate correlation of TNF-α genetic variation and idiopathic childhood ischemic stroke. Using the direct DNA sequencing method, polymorphisms in the TNF-α promoter region were genotyped in 67 Chinese patients with idiopathic childhood stroke and 70 controls. Among totally 7 single nucleotide polymorphisms identified in the TNF-α promoter region, the variant of the -863C/A is associated with increased risk of idiopathic childhood ischemic stroke in our study group. TNF-α molecule may have genetically as well as functionally an important role in the pathogenesis of idiopathic childhood ischemic stroke in the Chinese population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08830738
- Volume :
- 24
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 36332778
- Full Text :
- https://doi.org/10.1177/0883073808321046