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De-novo CD5 + B- prolymphocyte leukemia (PLL) presenting at younger age with favourable outcome.
- Source :
-
Turkish Journal of Hematology . Sep2008, Vol. 25 Issue 3, p149-151. 3p. 1 Black and White Photograph. - Publication Year :
- 2008
-
Abstract
- B-cell prolymphocytic leukemia (B-PLL) comprises 1% of chronic lymphocytic leukemias. CD5 positivity is seen in 1/3rd of cases which generally arise from pre existing CLL. They have longer median survival compared with de novo B-PLL which are commonly CD5 negative and are more aggressive with an older age of presentation. Herewith, we describe a 48-year-old male of de-novo CD5+ B-PLL presenting with minimal lymphadenopathy and massive splenomegaly with 90% atypical lymphoid cells in the peripheral smear and bone marrow. Immunophenotyping was strongly positive for CD5, CD45, CD19, CD22, FMC-7, S-Ig and CD38, moderately positive for CD 11c, weakly positive for CD23 and negative for CD-103 and ZAP 70. The patient responded well to fludarabine and cyclophosphamide and had an uneventful hospital course. Our case illustrates a de-novo B-PLL with aberrant CD5 positivity who had a short duration of illness, younger age at presentation and favourable treatment outcome. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Turkish
- ISSN :
- 13007777
- Volume :
- 25
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Turkish Journal of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 36333187