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Evidence of calpain/cdk5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro
- Source :
-
Neuropharmacology . Feb2009, Vol. 56 Issue 2, p422-428. 7p. - Publication Year :
- 2009
-
Abstract
- Abstract: Lithium reduced striatal neurodegeneration induced in rats by 3-nitropropionic acid inhibiting calpain activation. Lithium prevented an increase in cdk5 activity, as shown by the levels of the co-activator p35. Myocite enhancer factor 2 (MEF2), a downstream substrate for cdk5 with pro-survival activity, showed increased phosphorylation. In primary cultures of neurons treated with 3-NP, lithium also reduced protease activity mediated by calpain, cdk5 activation and cellular death. These observations indicate that lithium has a neuroprotective effect. Lithium treatment also reduced the intracellular increase in calcium induced by 3-NP. The finding that lithium mediates the modulation of the calpain/cdk5 pathway further supports its use in the treatment of neurodegenerative diseases. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00283908
- Volume :
- 56
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuropharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 36341494
- Full Text :
- https://doi.org/10.1016/j.neuropharm.2008.09.012