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Ex Uno Plura.

Authors :
Feau, Sonia
Schoenberger, Stephen P.
Source :
Science. 1/23/2009, Vol. 323 Issue 5913, p466-467. 2p.
Publication Year :
2009

Abstract

The article discusses two research papers concerned with how subsets of T cells that mediate acute and long-term protection to infection are derived from a single precursor. Effector cells are short-lived and numerous T cells that can deploy a variety of cytokine and cell contact-dependent cytotoxic mechanisms to control acute infection. Memory T cells effectively respond to reinfection by the same pathogen. These are both subsets of CD8+ cells. One paper shows that the T cell receptor, which is a heterodimeric protein that serves as the antigen-specific sensor for T cells, helps to generate the signals that allow a primed T cell to differentiate into a memory cell.

Details

Language :
English
ISSN :
00368075
Volume :
323
Issue :
5913
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
36430243
Full Text :
https://doi.org/10.1126/science.1169409