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İnsülin benzeri büyüme faktörleri (IGF): Egzersiz metabolizması ve kas dokusu üzerine etkileri.
- Source :
-
Journal of General Medicine / Genel Tıp Dergisi . 2008, Vol. 18 Issue 4, p177-184. 8p. 1 Chart. - Publication Year :
- 2008
-
Abstract
- Objective: The development and growing up of organism was regulated by hormones and factors effective in growth along axis of hypothalamus- hypophysis. In this study, effects of IGFs were aimed to investigate on bone and muscle metabolism and its regulation and response to exercise. Main Findings: Insulin-like growth factors (IGFs) is synthesized by liver and many of tissue are effective in somatic growth. IGFs have two important forms as IGF-I and IGF-II. IGF-II is effective on intrauterine growth, whereas IGF-I is more effective on postnatal growth. IGFs binding proteins were transported to target organs. Six binding proteins have been defined (IGF 1-6). The binding proteins have three different receptor in cell membrane, insulin receptor; Type-I receptor and Type-II receptor. IGFs affected via autocrine and paracrine mechanisms on bone and muscle. Conclusion: The effect of IGF on muscle tissue increase with mechanic stress (resistance exercise). Owing to this condition, exercise plays an effective role on preventing muscle atrophy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Turkish
- ISSN :
- 1301191X
- Volume :
- 18
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of General Medicine / Genel Tıp Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 36544420