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Pharmacodynamics and pharmacokinetics studies of phenoxazinium derivatives for antimalarial agent
- Source :
-
Bioorganic & Medicinal Chemistry . Feb2009, Vol. 17 Issue 4, p1481-1485. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: In vivo antimalarial drug candidates screening test was carried out on a series of water-soluble 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. Among them, 3-(diethylamino)-7-(piperidin-1-yl)phenoxazin-5-ium chloride (SSJ-206) showing highest efficacy was chosen for further pharmcodynamics and pharmacokinetics study. It was supported from these data that the phenoxazinium salts, SSJ-206, would be one of hopeful candidates as an oral antimalarial drug. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 17
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 36564339
- Full Text :
- https://doi.org/10.1016/j.bmc.2009.01.021