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Gamma-lactams—A novel scaffold for highly potent and selective α7 nicotinic acetylcholine receptor agonists
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2009, Vol. 19 Issue 5, p1287-1291. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: A novel class of α7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis γ-lactam scaffold has been optimized to reveal highly potent and selective α7 nAChR agonists with in vitro activity and selectivity and with good brain penetration in mice. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 36564509
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.01.073