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Simian T-Lymphotropic Virus Diversity among Nonhuman Primates, Cameroon.
- Source :
-
Emerging Infectious Diseases . Feb2009, Vol. 15 Issue 2, p175-184. 10p. 5 Diagrams, 4 Charts, 1 Map. - Publication Year :
- 2009
-
Abstract
- Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lymphotropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV-seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter-collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RETROVIRUSES
*T cells
*PHYLOGENY
*MONKEYS
*CERCOPITHECUS
*DNA
Subjects
Details
- Language :
- English
- ISSN :
- 10806040
- Volume :
- 15
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 36576561
- Full Text :
- https://doi.org/10.3201/eid1502.080584