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JAK2V617F mutation in essential thrombocythemia: correlation with clinical characteristics, response to therapy and long-term outcome in a cohort of 275 patients.
- Source :
-
Leukemia & Lymphoma . Feb2009, Vol. 50 Issue 2, p247-253. 7p. 3 Charts. - Publication Year :
- 2009
-
Abstract
- The JAK2V617F mutation occurs in 50% of patients with essential thrombocythemia (ET). We investigated the correlation between the JAK2V617F mutation and clinical and laboratory characteristics, thrombohemorrhagic risk and incidence of disease evolution in 275 patients with ET followed for a median follow-up of 7 years. JAK2V617F mutation was detected in 175 patients (64%), of whom 173 were heterozygous. Patients with the mutation were older and displayed higher hemoglobin and hematocrit levels, but lower platelet count. Cytotoxic treatment requirement was similar in the two groups, but patients with the mutation showed better responses. Incidence of thrombosis and disease evolution was comparable. JAK2 mutational status assessment was valuable to distinguish two populations of patients with ET, showing distinctive hematologic and clinical features. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THROMBOCYTOSIS
*GENETIC mutation
*HEMOGLOBINS
*HEMATOCRIT
*CARDIOVASCULAR diseases
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 50
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 36591766
- Full Text :
- https://doi.org/10.1080/10428190802688152