Stereoselective synthesis of (+)-secosyrin 1

Authors :: Gautam, D.
Venkateswara Rao, B.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2009, Vol. 50 Issue 15, p1693-1695. 3p.
Publication Year :: 2009
Abstract: Abstract: A Chiron approach for the synthesis of (+)-secosyrin 1 from d-mannitol has been described. The key steps are a stereoselective Wittig reaction and an intramolecular Michael addition on the disubstituted butenolide, leading to a highly stereoselective formation of the tertiary chiral centre of (+)-secosyrin 1. [Copyright &y& Elsevier]

Subjects :: *STEREOCHEMISTRY
*FURANS
*ORGANIC synthesis
*MANNITOL
*WITTIG reaction
*ADDITION reactions
*CHIRALITY

Language :: English
ISSN :: 00404039
Volume :: 50
Issue :: 15
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 36767257
Full Text :: https://doi.org/10.1016/j.tetlet.2009.01.106