Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome.

The article presents a retrospective cohort study which assessed the outcomes of patients taking clopidogrel with or without a proton pump inhibitor (PPI) after hospitalization for acute coronary syndrome (ACS). 8205 patients with ACS taking clopidogrel after discharge from 127 Veterans Affairs hospitals between October 1, 2003 and January 31, 2006 were included in the study. The main outcome was all-cause mortality or rehospitalization for ACS. Researchers found that concomitant use of clopidogrel and PPI was associated with an increased risk of adverse outcomes compared with clopidogrel without PPI.