O6-Methylguanine DNA Methyltransferase Immunoexpression in Nonfunctioning Pituitary Adenomas.

The article focuses on a report that assesses O6-methylguanine DNA methyltransferase (MGMT) expression in a series of patients with regrowing nonfunctioning pituitary adenomas (NFPA). The effectiveness of temozolomide (TMZ) in patients with progressive, regrowing tumors and a tumor-free patients is evaluated. The findings offer a rational for TMZ use as an alternative treatment approach for patients with regrowing NFPAs exhibiting low MGMT expression.