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Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2009, Vol. 19 Issue 7, p1903-1907. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: Topical microbicides offer women the opportunity to protect themselves from sexual HIV transmission under their own control. A series of poly[styrene-alt-(maleic anhydride)] derivatives were prepared by amidation or hydrolysis of the anhydride moiety. The derivatives were shown to be of low cell toxicity and effectively inhibited HIV-1 infections in an in vitro cellular model. Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 36970237
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.02.059