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Stereoselective synthesis of (2S,3S)-3-hydroxy-2-phenylpiperidine from d-mannitol
- Source :
-
Tetrahedron: Asymmetry . Feb2009, Vol. 20 Issue 2, p198-201. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: A novel stereoselective synthesis of N-Boc-(2S,3S)-3-hydroxy-2-phenylpiperidine was achieved from d-mannitol involving the highly stereoselective addition of phenyl Grignard to an allyl imine (de >98%) and ring-closing metathesis (RCM) in the key steps. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09574166
- Volume :
- 20
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Tetrahedron: Asymmetry
- Publication Type :
- Academic Journal
- Accession number :
- 36970504
- Full Text :
- https://doi.org/10.1016/j.tetasy.2008.12.005