Parameters of Soluble Immune Activation In Vivo Correlate Negatively With the Proliferative Capacity of Peripheral Blood Mononuclear Cells In Vitro in HIV-Infected Patients.

The article investigates the plasma of patients through interferon-y-mediated pathways and evaluates for associations with the proliferative responses of Peripheral Blood Mononuclear Cells (PBMCs) to mitrogens in vitro. Result shows that the in vitro proliferative capacity of PBMC was associated with viral load, CD4 counts and also tryptophan degradation. It was then concluded that the higher the degree of immune activation in vivo, the lower is the proliferative capacity of PBMC in vitro.