Back to Search
Start Over
γ-Oryzanol-loaded calcium pectinate microparticles reinforced with chitosan: Optimization and release characteristics
- Source :
-
Colloids & Surfaces B: Biointerfaces . May2009, Vol. 70 Issue 2, p213-217. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: Response surface methodology was used to optimize microparticle preparation conditions, including the ratio of pectin:gamma-oryzanol (OZ) (X 1), agitation speed (X 2), and the concentration of emulsifier (X 3), for maximal entrapment efficiency (EE) of OZ-loaded Ca pectinate microparticles. The optimized values of X 1, X 2, and X 3 were found to be 2.72:5.28, 1143.5rpm, and 2.61%, respectively. Experimental results obtained for the optimum formulation agreed favorably with the predicted results, indicating the usefulness of predicting models for EE. In order to evaluate the effect of chitosan-coating and blending on the release pattern of the entrapped OZ from microparticles, chitosan-coated and blended Ca pectinate microparticles were prepared. Release studies revealed that the chitosan treatments, especially the chitosan-coating, were effective in suppressing the release in both simulated gastric fluid (SGF) and intestinal fluid (SIF). [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 70
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 37158507
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2008.12.028