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DNA-Bound peptides control the mRNA transcription through CDK7
- Source :
-
Peptides . Apr2009, Vol. 30 Issue 4, p681-688. 8p. - Publication Year :
- 2009
-
Abstract
- Abstract: The degradation of intracytosolic proteins has been well described. However, the degradation pathway and physiological functions of the DNA-Bound peptides, which are free of degradation by peptidase of the post-ubiquitin–proteasome pathway, are still unclear. In this study, the DNA-Bound peptides were isolated from barley germ and two main fractions of about 25 different peptides were obtained. The DNA-Bound peptides were found to inhibit the proliferation of HeLa cells in a series of experiments. The DNA-Bound peptides also significantly inhibited in vitro and in vivo DNA transcription activity by regulating the expression and the corresponding functions of CDK7. Furthermore, signaling issues involving NFκB and ERK1/2 were observed. Such data suggests that DNA transcription could be inhibited by the DNA-Bound peptides via the CDK7 pathway. Thus we concluded that some of the post-proteasomal peptides were involved in the regulation of eukaryotic mRNA transcription. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01969781
- Volume :
- 30
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Peptides
- Publication Type :
- Academic Journal
- Accession number :
- 37225860
- Full Text :
- https://doi.org/10.1016/j.peptides.2008.11.008