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Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine
- Source :
-
Biochemical & Biophysical Research Communications . May2009, Vol. 382 Issue 2, p430-433. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (Dm-dNK) can additionally sensitize human cancer cell lines towards the anti-cancer drug gemcitabine. We show that this property is based on the Dm-dNK ability to efficiently phosphorylate gemcitabine. The 2.2Å resolution structure of Dm-dNK in complex with gemcitabine shows that the residues Tyr70 and Arg105 play a crucial role in the firm positioning of gemcitabine by extra interactions made by the fluoride atoms. This explains why gemcitabine is a good substrate for Dm-dNK. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 382
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 37352406
- Full Text :
- https://doi.org/10.1016/j.bbrc.2009.03.041