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The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in....

Authors :
Schutte, Hartwig
Witzenrath, Martin
Source :
American Journal of Physiology. Sep2000 Part 1 of 2, Vol. 279 Issue 3, pL496. 7p. 1 Chart, 3 Graphs.
Publication Year :
2000

Abstract

Investigates the enhancement of nitric oxide (NO)-mediated protection against vascular leakage by zaprinast, a phosphodiesterase inhibitor in reperfused lungs of the rabbit. Coadministration of nitric oxide and zaprinast; Elevation of pulmonary arterial pressure; Amplification of the beneficial effect of the NO-cyclic guanylic acid axis.

Details

Language :
English
ISSN :
00029513
Volume :
279
Issue :
3
Database :
Academic Search Index
Journal :
American Journal of Physiology
Publication Type :
Academic Journal
Accession number :
3737392