C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus.

The article reports on the results of research which was conducted in an effort to determine C-peptide levels after autologous nonmyeloblative hematopoietic stem cell transplantation in patients with newly diagnosed type one diabetes mellitus during a longer follow-up. Researchers conducted a prospective phase 1/2 study of 23 patients with type one diabetes mellitus. They found that after a mean follow-up of 29.8 months following stem cell transplantation in patients with newly diagnosed diabetes, C-peptide levels increased significantly and the majority of patients achieved insulin dependence and good glycemic control.