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Association of lower eosinophil-related T helper 2 (Th2) cytokines with coronary artery lesions in Kawasaki disease.
- Source :
-
Pediatric Allergy & Immunology . May2009, Vol. 20 Issue 3, p266-272. 7p. - Publication Year :
- 2009
-
Abstract
- Kawasaki disease (KD) is a systemic febrile vasculitis particular coronary artery involvement. Eosinophilia has been found in our and other studies in KD. This study further investigates whether eosinophil-related T helper 2 (Th2) cytokines or the activation marker (eosinophil cationic protein – ECP) is involved in KD with coronary artery lesions (CAL). A total of 95 KD patients were enrolled for this study. Plasma samples were subjected to the measurement of interleukin (IL)-4, IL-5, and eotaxin by Luminex-Bedalyte multiplex beadmates system and to the measurement of ECP by fluoroimmunoassay. Patients with KD had higher eosinophils than controls. Eosinophil-related mediators: IL-4, IL-5, eotaxin, and ECP levels were also higher in KD patients than controls before intravenous immunoglobulin (IVIG) treatment. After IVIG treatment, ECP decreased but IL-4, IL-5, and eotaxin increased significantly. The higher the IL-5 and eosinophil levels after IVIG treatment, the lower rate of CAL was found. Changes of eosinophils after IVIG treatment were positively correlated to changes of IL-5 levels but not ECP levels. An increase of eosinophils and IL-5, but not ECP levels after IVIG treatment, was inversely correlated with CAL formation in KD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09056157
- Volume :
- 20
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Pediatric Allergy & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 38015184
- Full Text :
- https://doi.org/10.1111/j.1399-3038.2008.00779.x