Adrenocorticotropic Hormone, Melanocyte-stimulating Hormone, and the Melanocortin Receptors: Revisiting the Work of Robert Schwyzer.

In 1977 Dr. Robert Schwyzer wrote the review ACTH: A Short Introductory Review, which provided a reference point for current structure/function studies on the interactions between adrenocorticotropic hormone and α-melanocyte-stimulating hormone and the melanocortin receptors. This mini review will evaluate how the predictions made in the 1977 review have held up and also propose a mechanism to explain the ligand selectivity properties of the melanocortin receptors. [ABSTRACT FROM AUTHOR]