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Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression
- Source :
-
Neuroscience Letters . Jun2009, Vol. 456 Issue 2, p49-53. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: Objective: The Beck Depression Inventory (BDI) is probably the most widely used depression scale. It has been suggested that it contains a two-factor structure measuring cognitive-affective (i.e. psychological) and somatic-vegetative depressive symptoms. In this study we aim to evaluate these factors by probing for their neural correlates. Methods: Neural responses evoked by emotional perception, relative to an emotional judgment task, were measured using functional magnetic resonance imaging (fMRI) in 20 medication-free patients with severe MDD. Psychological and somatic-vegetative symptoms were evaluated with the BDI. Results: Psychological symptoms correlated with signal changes in the dorsomedial and right ventrolateral prefrontal cortex, while somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. Conclusions: These preliminary findings demonstrate segregated neural representation of psychological and somatic-vegetative symptoms of MDD in different cortical regions. Thus, our results indicate that the two-factor structure of the BDI is related to distinct neural correlates. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 456
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 38323464
- Full Text :
- https://doi.org/10.1016/j.neulet.2009.03.097