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Change in Blood Coagulation Parameters After Total Body Irradiation.

Authors :
Cengiz, Mustafa
Göker, Hakan
Yazici, Gözde
Zorlu, Faruk
Büyükasik, Yahya
Kirazli, Serafettin
Akman, Ümit
Yildiz, Ferah
Dogan, Ali
Haznedaroglu, Ibrahim C.
Source :
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi. Sep2008, Vol. 18 Issue 3, p135-140. 6p. 3 Charts.
Publication Year :
2008

Abstract

We aim to test the changes of coagulation parameters after the TBI by thromboelastography. Eleven patients who underwent TBI between march 2005 and march 2006 in our department were included in this study. Blood samples were taken from all patients immediately before the delivery of TBI and 12 hours after the completion of TBI. Complete blood counts, partial thromboplastin time (aPTT), prothrombin time (PT), and the fibrinogen levels were measured. FIB-EXTEM, extrinsic (TEG-EXTEM), intrinsic (TEG-INTEM) clotting pathways, and platelet functions were measured by rotational thromboelastogram (ROTEM). All measured parameters were compared by using wilcoxon paired test. There was no difference in the PT, a PTT, thrombin and thrombocyte counts before and after TBI. However, maximum clot firmness was decreased after TBI in FIBTEM measurement (18.6 vs 15.5, p<0.05). The clot formation time was also significantly prolonged (115.8 vs 121.7 seconds, p<0.05 ) and maximum clot firmness was decreased in EXTEM measurements. The fibrinogen levels were significantly decreased after TBI. Our results demonstrated that the clot formation was significantly decreased in the early period after TBI. Prolongation of clot formation time and decrease in maximum clot firmness in extrinsic pathway after TBI indicates disturbance in platelet functions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1306133X
Volume :
18
Issue :
3
Database :
Academic Search Index
Journal :
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi
Publication Type :
Academic Journal
Accession number :
38590921