Korneometryczna ocena stopnia nawilżenia naskórka przy stosowaniu wybranych emolientów.

Introduction: Dry skin is a very common and serious clinical problem of about 15-20% of population. Aim of the study: Corneometric assessment of epidermis moisturizing after a single application of selected emollients: Physiogel® cream, Nivea® cream and 5% urea in eucerin. Material and methods: The study was conducted within a group of 37 people (37 women and 14 men) aged 19 to 62 years (average 42,1±12,8 years) with clinically dry skin. 37 people applied Physiogel® cream on the randomly chosen forearm skin, 17 people applied Nivea® cream and 20 people applied 5% urea in eucerin on the second forearm skin. Corneometric assessment were performed before (baseline) and 15, 30 min, 1, 2, 4, 6, 24 h after application of emollients. Results: The corneometric values significantly increased from the first measurement after 15 min of a single application of the Physiogel® cream, and the peak of the epidermis moisturizing was also observed after 15 min (p<0.001). The peak remained unchanged at the similar level up to 6 hours after application. The slow decrease of epidermis moisturizing was noticed in the following hours, but after 24 hours the corneometric values were still significantly higher than before application (p<0.001). The peak of the epidermis moisturizing was observed after 4 hours and remained unchanged at the similar level up to 6 hours after application of Nivea® cream and 5% urea in the eucerin vehicle. The slow decrease of epidermis moisturizing was noticed in the following hours. Physiogel® cream provided better moisturaization of the epidermis than Nivea® cream and 5% urea in the eucerin vehicle during the whole period of measurements (p≤0.001). Conclusions: The highest and quickest improvement of epidermis hydration is observed after a single application of Physiogel® cream containing structured physiological lipids. [ABSTRACT FROM AUTHOR]