The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERB.

The heme-regulated nuclear hormone receptor REV-ERB is one of the core transcription factors regulating circadian rhythms. We found that transcription by heme-bound REV-ERB is regulated by NO gas, and a crystal structure of the heme-bound protein uncovers the basis for heme and gas binding. [ABSTRACT FROM AUTHOR]