Lipopolysaccharide-induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro.

The article highlights an experimental laboratory research which determines the involvement of cyclic adenosine monophosphate (cAMP) in lipopolysaccharide (LPS)-induced breakdown of endothelial barrier functions in vivo and in vitro in Germany. The research focused on Wistar rats and cultured human microvascular endothelial cells. It noticed that LPS disrupts endothelial barrier properties by lowering intracellular cAMP.