Chemo-Enzymatic Total Synthesis of 3-Epiaustraline, Australine, and 7-Epialexine.

Describes the synthesis of tetrahydroxylated pyrrolizidines using a chemoenzymatic method utilizing a stereospecific aldol reaction coupled with selective bis-reductive amination. Potential of the method to access other stereosomers and analogues related to the hydroxylated pyrrolizidine class of alkaloids; Improved epoxidation of divinyl carbinol.