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Microbial transformation of epothilone A by Aspergillus niger AS 3.739.
- Source :
-
Journal of Asian Natural Products Research . Apr2009, Vol. 11 Issue 4, p357-364. 8p. 7 Diagrams, 3 Charts. - Publication Year :
- 2009
-
Abstract
- The microbiological transformation of epothilone A (1) by Aspergillus niger AS 3.739 afforded four main metabolites. Their structures were elucidated by 1H, 13C NMR and HSQC, COSY, HMBC, and NOESY spectra as trans-12,13-hydroxylated epothilone A (2), cis-12,13-hydroxylated epothilone A (3), trans-12,15-epoxidated epothilone A (4), and cis-12,15-epoxidated epothilone A (5). All four compounds were firstly found based on their stereochemistry. These new compounds displayed cytotoxicity against human breast carcinoma cells MCF-7 with IC50 9.88 μg/ml of 2, 2.52 μg/ml of 3, 9.88 μg/ml of 4, and 5.68 μg/ml of 5. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASPERGILLUS niger
*ASPERGILLUS
*CELL-mediated cytotoxicity
*CANCER cells
*CELLS
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 11
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 39254035
- Full Text :
- https://doi.org/10.1080/10286020902767732