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Administration of a new diabetes-specific enteral formula results in an improved 24h glucose profile in type 2 diabetic patients

Administration of a new diabetes-specific enteral formula results in an improved 24h glucose profile in type 2 diabetic patients

Authors :
Ceriello, Antonio
Lansink, Mirian
Rouws, Carlette H.F.C.
van Laere, Katrien M.J.
Frost, Gary S.
Source :
Diabetes Research & Clinical Practice. Jun2009, Vol. 84 Issue 3, p259-266. 8p.
Publication Year :
2009

Abstract

Abstract: Aims: Study the effect of several boluses of a new diabetes-specific formula (DSF) during the day on 24h glucose profile. Methods: In this randomized, controlled, double-blind, cross-over study 12 ambulatory type 2 diabetic patients were included. Subjects received a new DSF and an isocaloric standard fibre-containing formula (SF) while continuing their anti-diabetic medication. Subjects received 100% of their calculated daily energy requirements as bolus feeding every 3h (5 times/day, starting at 8.00a.m.±1h). Results: Glucose profiles were significantly better after administration of DSF compared with SF determined as mean glucose concentration (±SEM) (8.7±0.5 versus 9.6±0.6mmol/L, p <0.05 during 24h; 9.4±0.6 versus 10.7±0.6mmol/L, p <0.001 during daytime) or as incremental area under the curve during daytime (−44%; p <0.05). Subjects receiving DSF experienced less hyperglycaemic time over 24h (−26%; p <0.05) and during daytime (−30%; p <0.05). Furthermore, lower individual and mean (delta) peak glucose levels were found (p <0.05). No clinically relevant differences in gastrointestinal tolerance were observed. Conclusions: Using DSF resulted in significantly better 24h and postprandial glucose profiles than fibre-containing SF after bolus administration and may therefore help to improve glycaemic control in diabetic patients. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01688227
Volume :
84
Issue :
3
Database :
Academic Search Index
Journal :
Diabetes Research & Clinical Practice
Publication Type :
Academic Journal
Accession number :
39779051
Full Text :
https://doi.org/10.1016/j.diabres.2009.02.013