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Induction of Alpha/Beta Interferon by Myxoma Virus Is Selectively Abrogated When Primary Mouse Embryo Fibroblasts Become Immortalized.
- Source :
-
Journal of Virology . Jun2009, Vol. 83 Issue 11, p5928-5923. 1p. - Publication Year :
- 2009
-
Abstract
- Mouse embryo fibroblasts (MEFs) are a widely used cell culture system in life sciences, including virology. Here, we show that although primary MEFs are nonpermissive to myxoma virus replication, the corresponding immortalized MEFs support a highly productive myxoma virus infection. We further demonstrate that this permissive phenotype for myxoma virus in immortalized MEFs is due to the immortalization-associated selective block to the cellular alpha/beta interferon induction machinery involved in responding to myxoma virus challenge. Thus, our report presents a clear example, illustrating that a drastic phenotypic alteration can occur with respect to virus infection between primary cells and their immortalized counterparts. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERFERONS
*MYXOMA
*FIBROBLASTS
*CELL culture
*VIRUS diseases
*MICE
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 83
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 40090311
- Full Text :
- https://doi.org/10.1128/JVI.02587-08