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Design and optimization of renin inhibitors: Orally bioavailable alkyl amines
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2009, Vol. 19 Issue 13, p3541-3545. 5p. - Publication Year :
- 2009
-
Abstract
- Abstract: Structure-based drug design led to the identification of a novel class of potent, low MW alkylamine renin inhibitors. Oral administration of lead compound 21l, with MW of 508 and IC50 of 0.47nM, caused a sustained reduction in mean arterial blood pressure in a double transgenic rat model of hypertension. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 41240862
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.04.140