Comparison of virulence factors and expression of specific genes between uropathogenic Escherichia coli and avian pathogenic E. coil in a murine urinary tract infection model and a chicken challenge model.

The article discusses the study on the difference of virulence factors and gene expression between uropathogenic Escherichia coli (UPEC) and avian pathogenic E. coli (APEC) in murine urinary tract infection (UTI) and chicken model. The study reveals that UTIs are among the most common diseases worldwide which are acquired through UPEC infections. The capababilities of UPEC to reproduce in the intestine may appear to be the source of other diseases. Some iron-related genes are determined in both UTI and chicken model, showing that iron acquisition is significant for E. coli to survive in the urinary tract. The study also compares the transcriptional event of virulence genes in APEC and UPEC in vivo.