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Micronization of silybin by the emulsion solvent diffusion method
- Source :
-
International Journal of Pharmaceutics . Jul2009, Vol. 376 Issue 1/2, p116-122. 7p. - Publication Year :
- 2009
-
Abstract
- Abstract: Micronized silybin particles were successfully prepared by emulsion solvent diffusion method. Uniform spherical and rod-shaped particles with a mean size of 2.48 and 0.89μm could be obtained using sodium dodecyl sulfate (SDS) concentration of 0.1wt% at 30 and 15°C, respectively. The characterization of silybin particles by SEM and particle size distribution (PSD) indicated that with the increase of temperature from 15 to 30°C, the as-prepared particles became bigger and had a tendency to turn into spherical shapes; with the increase of SDS concentration from 0.02 to 0.1wt%, the span of PSD became narrower while the mean particle size kept almost unchanged. XRD patterns and FT-IR spectra showed that the spherical and rod-shaped silybin particles possessed decreased crystallinity; however, the chemical structure and components were similar to those of the commercial silybin powder. Dissolution tests demonstrated that both of the spherical and rod-shaped silybin particles exhibited significantly enhanced dissolution rate when compared to the commercial silybin powder. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03785173
- Volume :
- 376
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- International Journal of Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 41584726
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2009.04.028