1-(N,N-Diisopropylcarbamoyloxy)-1-tosyl-1-alkenes—a²d¹ Synthons via Tandem Umpolung.

1-(N,N-Diisopropylcarbamoyloxy)-1-tosyl-alkenes have been developed as an a²d¹ synthon via tandem umpolung. Upon addition of Grignard reagents and further quench by carbonyl compounds, this synthon produces α,α'-branched-α'-oxygenated ketones. Strategically, this widely applicable method installs respectively a carbanion unit and a carbonyl unit formally onto the α-carbon and the carbonyl center of an aldehyde in one-pot. [ABSTRACT FROM AUTHOR]