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Study of impregnation of poly( l-lactide- ran- ε-caprolactone) copolymers with useful compounds in supercritical carbon dioxide.
- Source :
-
Journal of Materials Science . Jul2009, Vol. 44 Issue 13, p3533-3541. 9p. 1 Diagram, 6 Charts, 7 Graphs. - Publication Year :
- 2009
-
Abstract
- Outstanding controlled release materials were developed using statistically random copolymers of l-lactide ( l-LA) with ε-caprolactone (CL) using Sn(oct)2 as a catalyst at 150 °C for 24 h without solvent. Preparation of novel controlled release materials was carried out using useful organic compounds with low boiling points and synthetic random copolymers composed of l-LA and CL as base materials under supercritical carbon dioxide (scCO2). Low-boiling-point compounds such as d-limonene, hinokitiol, and trans-2-hexenal were used. In impregnation experiments using scCO2, the amounts of low-boiling-point compounds increased with an increase in l-LA content. When enzymatic degradation of poly( l-LA- ran-CL) was performed using lipase PS, copolymers with higher CL contents degraded more rapidly than did copolymers with higher l-LA content. In contrast, enzymatic degradation of copolymers occurred to a higher degree with increased l-LA content in enzymatic degradation by proteinase K. In a controlled release experiment with poly( l-LA- ran-CL) (=73/27), after 400 h of degradation by proteinase K, the remaining weight of the copolymer pellet was 6% and the amount of d-limonene remaining in the pellet was 15%. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00222461
- Volume :
- 44
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Journal of Materials Science
- Publication Type :
- Academic Journal
- Accession number :
- 41779664
- Full Text :
- https://doi.org/10.1007/s10853-009-3477-9