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Prise en charge de 315épisodes neutropéniques fébriles dans un centre anticancéreux
- Source :
-
Medecine & Maladies Infectieuses . Jun2009, Vol. 39 Issue 6, p388-393. 6p. - Publication Year :
- 2009
-
Abstract
- Abstract: Management of febrile neutropenic patients is described in guidelines. Each cancer center can adapt these according to its local bacterial ecology. We present a retrospective study made in a cancer center from 2001 to 2003. Method: Three hundred and fifteen febrile neutropenic episodes after chemotherapy (66% for solid tumor) were analysed. Results: For 279episodes, no antibiotic therapy was given before admission. Clinical or radiological manifestations occurred in 46%; microbiologically documented infections by hemocultures in 28% (Gram positive: 42%; Gram negative: 51%) and by puncture in 14% (Gram negative: 58%). The length of pyrexia was inferior to 7days in 88% and neutropenia inferior 7days in 80.8%. 79.7% of episodes were treated with one of the three antibiotic therapy recommended by the center (ceftriaxone+tobramycin; ceftriaxone+ciprofloxacin; ceftriaxone+ofloxacin); 13.3% were treated with an other therapy; 7% received no antibiotic therapy. 68.5% of patients treated with one of the three antibiotic therapies, became afebrile without changing the antibiotic protocol. Conclusion: In our study, there were a majority of Gram negative bacteria except for Pseudomonas aeruginosa. The three antibiotic therapy recommended by the center (third generation cephalosporin+aminoglycosides or fluoroquinolones) were effective and glycopeptide was not necessary in first intention treatment. [Copyright &y& Elsevier]
Details
- Language :
- French
- ISSN :
- 0399077X
- Volume :
- 39
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Medecine & Maladies Infectieuses
- Publication Type :
- Academic Journal
- Accession number :
- 42223035
- Full Text :
- https://doi.org/10.1016/j.medmal.2008.10.014