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PANEL REACTIVE ANTIBODY IN THALASSEMIC SERUM INHIBITS PROLIFERATION AND DIFFERENTIATION OF CORD BLOOD CD34+ CELLS IN VITRO.
- Source :
-
Pediatric Hematology & Oncology . Jul2009, Vol. 26 Issue 5, p338-344. 7p. 1 Chart, 1 Graph. - Publication Year :
- 2009
-
Abstract
- Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34+ cells in vitro. On semisolid medium, CD34+ cells derived from cord blood were incubated with thalassemic serum, and colony-forming units were counted after 10 days of culture. After incubation with serum-specific panel reactive antibody, profound decreases were found in the numbers of CFU-GM, CFU-GEMM and BFU-E compared with controls. The results indicated that serum-specific panel reactive antibody might have an apparent inhibition effect on proliferation and differentiation of cord blood CD34+ cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08880018
- Volume :
- 26
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Pediatric Hematology & Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 42869071
- Full Text :
- https://doi.org/10.1080/08880010902976098