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Phase 1 Trial of Temozolomide Plus Irinotecan Plus O6-Benzylguanine in Adults With Recurrent Malignant Glioma.
- Source :
-
Cancer (0008543X) . 7/1/2009, Vol. 115 Issue 13, p2964-2970. 7p. 1 Chart. - Publication Year :
- 2009
-
Abstract
- The article presents a clinical trial in patients with recurrent or progressive malignant glioma (MG). The trial was intended to find the maximum tolerated dose (MTD) and toxicity of irinotecan (CPT-11) when distributed with O6-benzylguanine and temozolomide (TMZ). The trial shows that in both strata, the dose-fixing toxicities were hematologic and included in four leukopenia, neutropenia, thrombocytopenia and febrile neutropenia.
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 115
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 43007931
- Full Text :
- https://doi.org/10.1002/cncr.24336