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Biochemical Characterization of the HpxO Enzyme from Kiebsiella pneumoniae, a Novel FAD-Dependent Urate Oxidaset.
- Source :
-
Biochemistry . 4/14/2009, Vol. 48 Issue 14, p3033-3035. 3p. - Publication Year :
- 2009
-
Abstract
- The article offers information on the genetic study of HpxO enzyme from Klebsiella pneumoniae which was proposed to catalyze the hydroxylation of uric acid to 5-hydroxyisourate. It explores the prediction that HpxO is a flavin cofactor (FAD) dependent urate oxidase and look at its catalytic activity by cloning tagged proteins and analysing its absorption spectra. It also shows a mechanism for urate oxidation and microbial purine metabolism.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 48
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 43045958
- Full Text :
- https://doi.org/10.1021/bi900160b