Evidence of Porcine Endogenous Retroviruses in Porcine Factor VIII and Evaluation of Transmission to Recipients with Hemophilia.

Authors :: Heneine, Walid
Switzer, William M.
Shanmugam, Vedapuri
Rosales, Guillermo Vazquez
Matthews, Aprille
Sandstrom, Paul
Folks, Thomas M.
Soucie, J. Michael
Evatt, Bruce L.
Source :: Journal of Infectious Diseases. 2/15/2001, Vol. 183 Issue 4, p648. 5p. 2 Diagrams.
Publication Year :: 2001
Abstract: Studies the presence of porcine endogenous retrovirus (PERV) in plasma samples of pigs and in clinical lots of unheated porcine clotting factor VIII concentrate (Hyate:C). Background of the study; Reverse-transcriptase polymerase reaction testing of PERV RNA in pig serum/plasma samples and Hyate:C; RT activity screening in pig serum/plasma samples and Hyate:C products; PERV envelope subtype analysis; Results; Discussion.

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