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MDM2 309 T/G polymorphism is associated with lung cancer risk among Asians
- Source :
-
European Journal of Cancer . Jul2009, Vol. 45 Issue 11, p2023-2026. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: Published data on the association between MDM2 309 T/G polymorphism and lung cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of eight studies including 6063 cases and 6678 controls were involved in this meta-analysis. Overall, significantly elevated lung cancer risk was associated with GG variant genotype in recessive model when all the eligible studies were pooled into the meta-analysis (OR=1.17; 95% CI=1.02–1.34; P heterogeneity =0.06). In the subgroup analysis by ethnicity, significantly increased risks were found among Asians for TG versus TT (OR=1.20; 95% CI=1.05–1.37; P heterogeneity =0.30), GG versus TT (OR = 1.34; 95% CI=1.01–1.79; P heterogeneity =0.03) and dominant model (OR=1.26; 95% CI=1.11–1.43; P heterogeneity =0.14). However, no significant associations were found in both Europeans and Africans for all genetic models. This meta-analysis suggests that the MDM2 309G allele is a low-penetrant risk factor for developing lung cancer in Asians. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 45
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 43167865
- Full Text :
- https://doi.org/10.1016/j.ejca.2009.02.002